CNS Disorders Programs & Research

It’s an exciting time in neuroscience at Sage.

The human brain is a network of billions of nerve cells, connected in complex electrical circuits to communicate. Brain function and mental health depend on proper functioning of these circuits. The flow of information among these circuits is managed by neural regulatory pathways including the GABA and NMDA receptors systems.

Sage has a robust portfolio of fully-owned, novel drug candidates being developed for disorders of the brain and central nervous system (CNS). Our proprietary compounds target the GABA and NMDA receptor systems. Dysfunction in these systems is known to be at the core of numerous disorders.

Translational data drives efficiency in our drug development approach

We use a translational research strategy to explore the activity of our compounds, and their potential in the treatment of disorders of the brain and central nervous system. Our distinct approach begins by conducting small clinical studies to evaluate activity and methodology. We measure biomarkers—from electrical activity to functional brain imaging—to gain insight into how brain cells are communicating with each other. These tools help us understand targets in context – and then inform the design of later stage clinical trials in well-defined patient populations.

Our lead product, designated by FDA as a breakthrough therapy for the treatment of postpartum depression, was recently approved by the FDA pending DEA scheduling. We are developing next generation modulators, including SAGE-217 and SAGE-718, in various CNS disorders.