Our Programs

We are developing new medicines to make life better for patients suffering from rare, life-threatening CNS disorders.

Our different approach to drug discovery and development has allowed us to create and advance multiple candidates with the potential to treat a range of central nervous system (CNS) disorders.

Next-Generation Neurosteroids

Our proprietary approach to drug discovery and development has generated selective compounds with precise pharmacologic properties that may be applied to the treatment of multiple CNS disorders. These compounds, which we call next-generation neurosteroids, have improved pharmacokinetic properties that may allow for both oral availability and improved therapeutic indexes. As a result, they may be better suited for long-term, or chronic, use. SAGE-689 and SAGE-217 are next-generation neurosteroids we have selected as clinical candidates.

Our Programs

Brexanolone (formerly SAGE-547)

Our lead product candidate, brexanolone, is administered as an intravenous therapy designed to correct imbalances in GABA signaling within the brain.1 Brexanolone injection is a proprietary formulation of allopregnanolone, a naturally-occurring nerve signaling molecule, known to modulate GABA receptor activity.

Brexanolone is in Phase 3 clinical development as an acute interventional treatment for postpartum depression and has been granted Breakthrough Therapy designation by the U.S. Food and Drug Adminstration and PRIME designation by the European Medicines Agency.

Learn more about the results of SAGE's clinical trials.

 

REFERENCES

  1. Majewska et al, Science, 1986.

SAGE-217

SAGE-217 is a novel, selective, next generation GABAA positive allosteric modulator that shares similar pharmacology properties to brexanolone. We are initially developing SAGE-217 as a once-daily, oral therapy for treatment of various CNS disorders.

Collaboration

Sage engages with the broader scientific and clinical community.

Collaborations are a significant and pivotal part of our research activities at Sage Therapeutics. We seek to understand the underlying biology and mechanisms of CNS disorders, with particular focus on the role of GABA and NMDA receptors. We welcome the opportunity to discuss potential collaborations with researchers, who share our goal to make a difference in the lives of patients with CNS disorders.

To discuss potential research collaboration opportunities with Sage contact us at collaboration@sagerx.com.