Sage is developing potential therapies for a wide range of CNS disorders.
We focus our research and development efforts on modulation of GABA and NMDA receptors—two critical neurotransmitter systems. The GABA system is the major inhibitory signaling pathway of the brain and central nervous system (CNS); NMDA is the major excitatory pathway. Both contribute significantly to regulating CNS function. Dysfunction in these two systems is known to be at the core of numerous psychiatric and neurological disorders.
The human brain is a network of billions of nerve cells, connected in complex electrical circuits to communicate. Brain health and function depend on these circuits. The flow of information among these circuits is managed by neural regulatory pathways including the GABA and NMDA receptors systems.