Parkinson’s Disease
Parkinson’s disease is a chronic and progressive movement disorder that affects approximately 700,000 people in the U.S. In this disease, nerve cells in the brain slowly stop producing dopamine, the neurotransmitter responsible for coordinating movement. As Parkinson’s disease progresses, dopamine produced in the brain decreases, leaving patients less able to direct their movement. Parkinson’s disease may cause tremors, stiffness, slow movement and balance trouble, as well as mood changes and sleep difficulties. Current treatments for Parkinson’s disease focus on dopamine replacement, and are effective in reducing symptoms initially, but lose effectiveness over time.
GABA receptors may be a possible therapeutic target in the treatment of Parkinson’s disease. GABA signaling is known to help regulate the nerve cells that produce dopamine. Researchers have also found decreased levels of allopregnanolone, a naturally-occurring GABA modulator, in patients with Parkinson’s disease.